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Our present findings indicate that the administration of LFD with ALA was associated with lower concentrations of leptin

We found that serotonin, dopamine, gamma-aminobutyric acid, norepinephrine, N-acetyl-L-aspartic acid, anandamide, and tryptophan were downregulated in the brain, while kynurenine, myo-inositol, hydroxykynurenine, and the kynurenine to tryptophan ratio were upregulated

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Suppressor of cytokine signaling (SOCS) proteins, most notably the SOCS-3, inhibit insulin signaling by preventing IRS protein activation through direct molecular interactions and altered protein stability in metabolically active tissues (165)