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Correspondingly, the mortality rate rose from 0.09 (95% UI, 0.01 to 0.22) per 100,000 in 1990 to 0.12 (95% UI, 0.02 to 0.29) per 100,000 in 2021, representing a 30.73% (95% UI, 15.0750.79) increase

Individuals with a homozygous A allele of the CYP1A2 gene tend to produce more cytochrome P450, an enzyme responsible for about 95% of caffeine metabolism, and consequently metabolize CAF more quickly

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A key point of our study is our finding of a reduction of glutathione in NTG patients, suggesting that excessive oxidative stress may contribute to optic nerve damage and RGC loss independently of high IOP in glaucoma