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Abbreviations ABCC2: ATP binding cassette subfamily C member 2 AGXT: Alanine glyoxylate aminotransfer-ase AI: Artificial intelligence Akt2: Protein kinase B APE1: Apurinic/apyrimidinic endonuclease ASCO: American Society of Clinical Oncology ASCO: American Society of clinical Oncology AT2: Angiotensin II type 2 ATP: Adenosine-triphosphate ATP7A: ATPase Copper Transport-ing Alpha BMI: Body mass index Cav2 1: Calcium voltage-gated calcium channel alpha2/delta subunit CCL2: C-C motif chemokine 2 CCR2: C-C-Motif Receptor 2 CD4 +: Cluster of Differentiation 4 receptors CD8 +: Cluster of Differentiation 8 receptors CIPN: Chemotherapy-induced peripheral neuropathy CNS: Central nervous system COX-2: Cyclooxygenase-2 CRC: Colorectal cancer CTR1: Copper transport 1 CTRs: Copper transpo-rters CXCR1: CXC chemokine receptor 1 CXCR2: CXC chemokine receptor 2 DDTC: Diethyldithiocarbamate DNA: Deoxyribonucleic acid DRG: Dorsal root ganglion EAAT1: Recombinant Excitatory Amino Acid Transporter 1 EORTC: European Organization for Research and Treatment of Cancer EPM: Electrophysiological measurements ERK1/2: Extracellular regulated kinase1/2 GABA: -aminobutyric acid GAT-1: GABA transporter subtype 1 GF: Germ-free GFAP: Glial fibrillary acidic protein GJG: Goshajinkigan GLAST: Glutamate/aspart-ate transporter GLT-1: Glutamate transporter-1 GM1: Monosialotetra-hexosylganglioside GSTP1: Glutathione S-transferase pi 1 HCN1: Hyperpolarizationactivated cyclic nucleotide-gated channel 1 HCNs: Hyperpolarization-activated channels HMGB1: High mobility group box 1 HPGC: Hydroxyprogesterone caproate hTRPA1: Human TRPA1 IB: Investigators Brochure Iba1: Ionized calcium binding adapter molecule 1 IENFs: Intraepidermal nerve fibers IL-8: Interleukin-8 INCAT: Inflammatory Neuropathy Cause and Treatment JNK/Sapk: c-JunNH2-terminal kinase /stress activated protein kinase K2P: Two pore potassium channels KCNN3: Potassium channel SK3 LDI: Laser Doppler imager LPS: Lipopolysaccharides MAMPs: Microbe-associated molecular patterns mISS: Group sensory sum score MMP9: Matrix metallopeptidase 9 MnSOD: Manganese superoxide dismutase MSCs: Mesenchymal stem cells NCI-CTC: National Cancer Institute-Common Toxicity Criteria NGF: Mus musculus nerve growth factor Nrf2: NF-E2 p45-related factor 2 OATP1B2: Organic aniontransporting polypeptide 1B2 OCT2: Recombinant Octamer Binding Transcription Factor 2 OCTN2: Organic cation transporter-2 OCTs: Organic cation transport-ters OHP: Oxaliplatin OIPN: Oxaliplatin-induced peripheral neurotoxicity OXA: Oxaliplatin PI3K: Phosphatidylinositide 3-kinases PKC: Protein kinase C PO: Per os p38: Phosphoprotein 38 QST: Quantitative sensory tests ROS: Reactive oxygen species rhuLIF: Recombinant human leukemia inhibitory factor rTMS: Repetitive transcranial magnetic stimulation S1P: Sphingosine-1-phosphate Sapk: Stress activated protein kinase SK3: Small-conductance calcium-activated potassium channel 3 SNRI: Serotonin-noradrenaline reuptake inhibitor SPF: Specified Pathogen Free S1P2: Sphingosine-1-phosphate receptor2 S1PR1: Sphingosine-1-Phosphate Receptor 1 TLR: Toll-like receptors TLR4: Toll-like receptors 4 TNSc: Total Neuropathy Score clinical version TRAAK: TWIK-related arachidonic acid-stimulated K+ channel TREK-1: TWIK-Related K + Channel 1 TRPA1: TRP ankyrin 1 TRPM8: Transient receptor potential cation channel, subfamily M, member 8 References Loprinzi CL, Lacchetti C, Bleeker J, Cavaletti G, Chauhan C, Hertz DL, et al