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Cell Stem Cell 19 , 2337 (2016)

[10] recently showed the benefit of GH replacement therapy over a 15 year period increasing BMD in adults with adult onset of GHD

The manuscript highlights how DDSsincluding stimuli-responsive nanoparticles, targeted ligands, and biodegradable carriersenhance solubility, bioavailability, and tissue-specific delivery of urate-lowering agents (e.g., allopurinol and febuxostat) and anti-inflammatory therapies (e.g., colchicine and IL-1 inhibitors) (Liu S