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Ten minutes post-heparinization, the left pulmonary hilum was occluded at end-expiration using a non-traumatic microvascular clamp

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SOD1 Misfolding Is Associated with Neurodegeneration Mutant SOD1 protein misfolding has been implicated in spinal cord motor neuron degeneration in familial ALS linked to SOD1 gene mutations ( SOD1 linked familial ALS) for over 25 years.[ 12 , 113a , 164 ] Accumulating evidence suggests wildtype SOD1 misfolding and dysfunction may also contribute to the death of spinal cord motor neurons in sporadic ALS,[ 90b , 110 , 125 , 165 ] substantia nigra pars compacta (SNc) dopamine neurons in Parkinson's disease,[ 13 , 91 , 166 ] and neurons within the frontal cortex and hippocampus in Alzheimer's disease.[ 91 , 167 ] Protein misfolding has dual implications

10.1080/07420520902924939 Chronobiol Int