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Combination approaches, blending prooxidants for cancer with antioxidants for protection, are gaining traction

Its journey from a lab synthesis in the 20th century to a staple among supplement formulas reflects its enduring relevance

Importantly, either genetic silencing of NCOA4 or treatment with the iron chelator deferoxamine (DFO) significantly attenuated these pathological changes, resulting in over 60% improvement in neuronal survival (Plascencia-Villa and Perry, 2021)