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[103] Due to safety concerns, including reports of hepatotoxicity and limitations in clinical evidence, the Committee on Herbal Medicinal Products (HMPC) concluded in 2017 that the benefit-risk balance for the oral use of kava in the treatment of anxiety disorders is unfavorable, and therefore a European Union herbal monograph could not be established

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Also, get help if you wake at night to use the bathroom for weeks

Most compounding pharmacies assign a beyond-use date (BUD) of 28 to 90 days from compounding for refrigerated vials