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Complete microglial depletion or prolonged broad inhibition may be too severe, especially considering that microglial homeostatic functions are necessary for synaptic maintenance and immune surveillance

[DOI] [PMC free article] [PubMed] [Google Scholar] 43.Kerley C.P., Elnazir B., Faul J., Cormican L

The concentration of leukotriene D(4) (LTD(4)), which is usually not detectable, was highly increased, whereas LTE(4), the major urinary metabolite in humans, was completely absent