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DeWilde S, Carey IM, Richards N, Hilton SR, Cook DG

Zhou L, Mozaffaritabar S, Kolonics A, Kawamura T, Koike A, Kringer J, et al

Another function of carnitine in human metabolism is its involvement in the detoxification process of toxic compounds (such as some foreign substances, including ampicillin, valproic acid, and salicylic acid, as well as toxic substances generated endogenously via metabolism), which are jointly excreted by the kidneys with carnitine (82)

78,80,81,82 Approximately 10% of them are copy number variations (CNVs) that disrupt protein coding, including chromosomal duplications, large deletions, inversions, and translocations, such as 1q21.1 duplications or deletions, 3q29 deletions, 7q11.23 duplications, 15q11-q13 deletions, 15q13.3 microdeletions, 15q11-13 duplications, 17q12 deletions, 22q11.2 deletions and 22q13.33 duplications or deletions