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Uraemic cardiomyopathy is characterized by extensive metabolic remodelling, including secondary carnitine deficiency, reduced fatty acid use, enhanced glucose utilization, mitochondrial dysfunction and altered expression of metabolic regulatory genes, which collectively result in impaired energetics

J Egypt Women's Dermatol Soc

Impact of antioxidant supplementation on chemotherapeutic toxicity: a systematic review of the evidence from randomized controlled trials

Additionally, damaged mitochondria release mtDNA into the cytosol, activating the innate immune system via damage-associated molecular patterns (DAMPs) (251, 377), modulating both innate and adaptive immune responses (377379)