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For example, intranasal insulin has been shown to enhance memory and reduce progression of white matter hyperintensity volume over 12 months, supporting its potential as a BBB-bypass therapeutic via olfactory and trigeminal pathways (Kellar et al., 2021)

Grk6 knockdown reduces cellular insulin levels, and attenuates insulin secretion, but enhances proinsulin secretion consistent with decreased processing [138]