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A higher dosage can cause life-threatening health issues including renal failure or blood poisoning, which is why several nations have outlawed its usage

In another study of schizophrenic patients (N=84), Berk et al 16 undertook a randomized, double-blind, placebo-controlled trial and found that NAC, administered at 1g twice daily for 24 weeks, was a moderately effective augmentation strategy and resulted in improvement in the study scales assessing positive and negative symptoms as well as overall functioning

First, although it was a prospective multicenter trial, it was still a single-arm study without a placebo

doi: 10.1186/1465-9921-10-101