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Moreover, a key challenge is balancing the desired anti-tumor immune effects with potential systemic metabolic side effects, such as dyslipidemia, which has been observed with some FXR agonists (132)

211 A randomized controlled trial involving 100 CKD patients reported that consuming 3,666 mg EPA and DHA daily was not more effective than corn oil at reducing urine albumin levels, but the formulation did improve blood vessel function and lower triglyceride levels more than corn oil

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Stimulation of BODIPY-loaded RPE cells with Cys 2 starvation or with BSO/erastin treatment increased ROS generation as measured by increased rate of BODIPY oxidation (Fig