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Through recombinant or non-recombinant approaches, multiple antigens have been displayed on spore surfaces, resulting in strong mucosal and systemic immune responses [227]

Additionally, individual characteristics (such as sex and genetic variations), folate stores and the availability of other nutrients (vitamin C, vitamin B12, vitamin B6, niacin, riboflavin or choline) influence the bioavailability of both dietary and synthetic folate (46)