hepatic glutathione depletion deficiency-elicited reprogramming of metabolism protects against alcohol-induced steatosis Depletion of hepatic glutathione and
Depletion of hepatic glutathione and selective protein oxidation and inhibition of lipogenesis Glutathione Depletion Pathways 1. Precursor Depletion Key bottleneck: Cysteine availability. Source: Diet or hepatic transsulfuration (methionine homocysteine cysteine). Failure mode: Downregulation of cystathionine lyase (CSE) during Chronic Glutathione Depletion Confers Protection against Alcohol induced Steatosis: Implication for Redox Activation of AMP activated Protein Kinase Pathway Scientific Reports Acute kidney injury model established by systemic glutathione depletion in mice Matsubara 2019 Journal of Applied Toxicology Wiley Online Library
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