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26 Managing HU in patients with renal impairment poses unique challenges, emphasizing the importance of early detection and intervention to mitigate renal complications

Further research into novel synthetic strategies, such as the development of sulfinate ester intermediates or DAG (diacetone-d-glucofuranose) methodologies, could provide more efficient and versatile routes for producing SFN and its analogues

Potassium homeostasis is also critical to prevent adverse events in patients with cardiovascular disease

5.2 Dose effect and safety issues 5.2.1 Dose-dependent safety concerns for functional food active ingredients Emerging evidence reveals significant population-specific toxicity risks for several widely consumed functional food ingredients, with genetic factors, smoking status, and concurrent medications dramatically altering safety profiles (239)