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Roxadustat impairs the neuronal redox balance through a PFKFB3-dependent reduction of NADPH production in the pentose phosphate pathway Cumulative evidence indicates that neurons have a lower glycolytic rate than astrocytes, and a significant proportion of glucose-6-phosphate (G6P) is directed towards the pentose-phosphate pathway (PPP) 41 , 42

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For example, it can impair cognitive function, memory, and coordination, making it difficult to communicate effectively and make sound decisions

Considerations Human data is limited, with most evidence from animal studies and user reports