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Hirano T, Ishihara K, Hibi M

McEwan, W

It's associated with an increased risk of AMD due to oxidative pathways and reduced intake of protective nutrients like Zn and vitamins

However, this may change dramatically under some conditions, e.g., in patients with high-dose methotrexate therapy, an anticancer drug that, by inhibiting dihydrofolate reductase, inhibits the tetrahydrofolate-catalyzed recycling of methionine from homocysteine