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145,146 In one controlled trial, 198 airline passengers with moderate to high risk of venous thrombosis were given either pycnogenol, at 200 mg before and during a long flight (averaging 8 hours 15 minutes) plus 100 mg the next day, or placebo

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doi: 10.1056/NEJMoa1411087 9 LokhorstHMPlesnerTLaubachJPNahiHGimsingPHanssonMet al

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