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Epigenetic clocks based on DNA methylation patterns have revealed accelerated epigenetic ageing in PD patients, suggesting a potential role for agerelated transcriptional dysregulation in disease pathogenesis [65, 66]

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The development of the nervous system in progeny may be influenced epigenetically by molecules associated with one-carbon metabolism, such as betaine, choline, and folate (Ars et al., 2019)