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ICRs Regarding Improvement Activities Submission ( 414.1305, 414.1355, 414.1360, and 414.1365) We did not propose to update our currently approved burden for improvement activities submissions as a result of policy provisions finalized in section IV.A.4.e.(3) of this final rule

MOTS-c may not fit research involving: Models where pure, rapid adipose tissue reduction is the only metric Research requiring oral bioavailability (MOTS-c is typically injected due to peptide degradation in the stomach) 5-Amino-1MQ may not fit research involving: Models focused on insulin sensitivity (it does not directly impact insulin receptors) Longevity research focused on mitochondrial biogenesis (it acts on NAD+ in fat, not mitochondrial genesis) Studies looking for exercise-mimetic effects on skeletal muscle Common Mistakes Mistake: Classifying 5-Amino-1MQ as a peptide