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These mediators diffuse through the synovial fluid to the cartilage surface, where they drive chondrocytes toward catabolic, hypertrophic, or senescent phenotypes, upregulate MMPs and aggrecanases, suppress COL2A1 and ACAN expression, and promote oxidative stress and ferroptosis, thereby accelerating ECM breakdown (Wang et al., 2022)

PT-141 (bremelanotide): effective in sublingual form PT-141, or bremelanotide, is a melanocortin receptor agonist used for sexual dysfunction

10.1111/jnc.13361 23 CockH

Even better, whip up a vitamin C smoothie packed with strawberries, oranges, kiwis, and a banana for your daily dose of potassium