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Figure 4 Figure 5 The downstream effects of HIF activation are extensive and include upregulation of various genes and pathways ( Figure 6 ), involved in glycolysis, lactate shuttling & acid-base balance, Angiogenesis & Vascular Remodeling, erythropoiesis & iron metabolism, cell survival & stress response, lipid & amino acid metabolism and Immune Modulation (3335)

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Hautala AJ, Rankinen T, Kiviniemi AM, Mkikallio TH, Huikuri HV, Bouchard C, Tulppo MP (2006) Heart rate recovery after maximal exercise is associated with acetylcholine receptor M2 ( CHRM2) gene polymorphism

Reprogramming metabolism with metformin improves tumor oxygenation and radiotherapy response