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Extinction coefficients of HT adducts were measured in the presence of a twofold excess of HT protein to ensure quantitative reaction of the ligand

The answer often lies in how they're delivered to our bodies

J Pharmacol Exp Ther 360(1):201205 Michel-Flutot P, Efthimiadi L, Djerbal L et al (2022) AMPK-Nrf2 signaling pathway in phrenic motoneurons following cervical spinal cord injury