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The complex of ferritin combined with NCOA4 is transported to lysosomes for degradation, subsequently releasing iron for utilization in cellular physiological activities

Molecules 24(14):2544 Al-Anbaky Q, Al-Karakooly Z, Kilaparty SP, Agrawal M, Albkuri YM, RanguMagar AB, Ghosh A, Ali N (2016) Cytotoxicity of manganese (III) complex in human breast adenocarcinoma cell line is mediated by the generation of reactive oxygen species followed by mitochondrial damage

These studies confirmed the neuroprotective effects of kaempferol in vitro models

If the published research runs 48 weeks, a protocol should match that duration at minimum