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With regard to measure reporting, we estimate a decrease in burden of 3 hours (38 REHs 50 percent of REHs 0.167 hours per REH) at a savings of $175 (3 hours $55.06/hour) for voluntary reporting for the CY 2025 reporting period and 6 hours annually (38 REHs 0.167 hours) at a savings of $349 (6 hours $55.06/hour) for mandatory reporting beginning with the CY 2026 reporting period

Look for human evidence and exact approved-use language before trusting a longevity claim

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Dose adjustments between standard increments The FDA titration schedule jumps from 0.25 to 0.5 to 1.0 mg