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188,193 HSPs in chemotherapy and radiotherapy resistance HSPs in chemotherapy resistance HSPs play a critical role in mediating resistance to chemotherapy and radiotherapy

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The structure of Glutathione Glutathione (5-L-Glutamyl-L-cysteinylglycine) is synthesized by glutamate-cysteine ligase (GCL) and glutathione synthase (GSS)

While synergism and additivity allow for achieving better effects with lower drug concentrations, clinical data suggest that independent drug action can also significantly improve patient outcomes (69)