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High glycemic index carbohydrates, such as simple sugars, are not the most recommended options for cancer patients, as they trigger hyperglycemia, oxidative stress, glucose intolerance and stimulate an increase in insulin levels (144) and it is consistently reported in human literature, but not in veterinary literature

189,190 The invasive potential of these cells is driven by upregulated signaling pathways, including L1CAM, ephrin-B2, 191 and epithelialmesenchymal transition (EMT)-associated factors such as twist-related protein 1 (TWIST1), SOX2, and signal transducer and activator of transcription 3 (STAT3)

There is an optimal working point on this, which may only move slightly along the working curve

Current proposed treatments were classified into two categories: (i) one-size-fits-all strategies, which can potentially be used to treat various MDs regardless of the underlying genetic mutation, and (ii) precision medicine approaches, aimed at treating a specific MDs with a particular mutation or distinct metabolic characteristic