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Another form of renal toxicity, generally associated with NSAIDs, is seen in patients with prerenal conditions leading to the reduction in renal blood flow or blood volume, where the renal prostaglandins have a supportive role in maintaining renal perfusion

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Despite Dihexas structural derivation from Ang IV, mechanistic studies have established that the compound does not act through the classical AT 4 receptor (insulin-regulated aminopeptidase, IRAP)