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Gastrointestinal side-effects, such as appetite suppression, diarrhoea, epigastric discomfort, heartburn, nausea and vomiting, have been reported in less than 1% of patients

doi: 10.3390/ijerph7052337

It appeared that the sequence CpG within the entire genome is methylated, because of diminished ability of Sss I methylase to transfer methyl groups from S- adenosylmethione (SAM) to DNA