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Membranes were incubated with anti-histone H3 antibody (1:1000, cat# ab1791, lot# 1015880-4, Abcam, Cambridge, UK), anti-NF-B p65 antibody (1:1000, cat# ab16502, lot# 1051015778-1, Abcam), anti-HIF-1 antibody (1:1000, cat# 14179S, lot# 4, Cell Signaling Technology, Denver, MA, USA), or anti--Actin antibody (1:2000, cat# 8457S, lot# 9, Cell Signaling Technology)