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When this equilibrium collapses, misfolded, aggregated, or damaged proteins accumulate, driving organelle dysfunction, maladaptive stress signaling, and disease progression

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In order to obtain a clinicopathological correlation of these morphological abnormalities of the RPE and photoreceptors, and to demonstrate that the visual function decline in aged VEGFA hyper mice can be rescued by targeting NLRP3 inflammasome components, we performed darkadapted (to assess mainly rod function) and lightadapted (to assess mainly cone function) electroretinograms (ERGs) in 21monthold mice of these experimental groups