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Leukotrienes are lipid mediators synthesized through the enzymatic conversion of arachidonic acid, a molecule release from the cell membrane after the activation of the cellular phospholipase A2

Overall, SCFAs significantly regulate intestinal metabolism, immunity, and barrier function

This process apparently starts when the VEGF protein, which is considered to be secreted by oxygen-deprived cells during a hypoxic response, and may bind to VEGF receptors on the surface of endothelial cells

It may therefore be that more 1 H-MRS studies are required to more fully determine whether these post-mortem findings are replicated in vivo