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DNA damage results in activation of ATM and ATR, which results in stabilization of the TP53 protein causing increased levels of cell cycle inhibitors, including CDKN1A/p21 Cip , CDKN1B/p27 Kip1 , and CDKN1C/p57 Kip2 [33]

Th1/Th2/Th17/Treg cytokine imbalance in systemic lupus erythematosus (SLE) patients: Correlation with disease activity

On the other hand, testosterone may increase male vulnerability to an adverse illness course compared to estrogen 56 , attributed to its narrower and sometimes unfavorable neuroprotection and neurotransmitter modulation profile 57

In GCLC-deficient T cells, excessive ROS accumulation due to impaired GSH biosynthesis inhibits calcineurin function, thus suppressing NFAT activation and impairing T cell metabolic reprogramming