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Group Comparisons at Week 8 : Group 1 (topical and oral placebo) MI: 385.69 94.38 Group 2 (topical GSH, oral placebo) MI: 330.69 87.90 Group 3 (oral GSH, topical placebo) MI: 347.00 81.77 Group 4 (topical and oral GSH) MI: 314.35 70.13 P - values for Group Comparisons : Group 1 vs Group 2: P = 0

While that's substantially higher than the 600mg starting dose we generally favor for people new to NAC, it reflects the GlyNAC protocols studied in healthy-aging research.34 57 58 Some readers may prefer to start with a smaller serving for tolerability, but the clinical research on GlyNAC has generally evaluated gram-level doses of both ingredients, so it's unclear whether substantially lower amounts would provide the same benefits

The bottom of the meniscus (the curved surface of the liquid) should align with your target mark

10.1007/s12035-023-03499-1 93 LiY.LiuA.ChenK.LiL.ZhangX.ZouF.et al (2024d)