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Incidence and prognostic significance of atrial fibrillation in acute myocardial infarction: the GISSI-3 data

This just-formed superoxide, together with its reduced metabolites, can interact with a great number of different naturally occurring body biomolecules, at least partially leading to the development of many diseases such as cardiovascular disease, cancer, chronic inam- mation, dementia, and amyotrophic lateral sclerosis, among others [ 140 , 141 ]

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127 For instance, low-dose metformin treatment adjuvant to chemotherapy significantly prolonged the OS of patients diagnosed with ovarian cancer