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Accordingly, we have recently reported that plantaris muscle from the same pravastatin treated mice model presented mild mitochondrial oxidative stress and higher sensitivity to Ca 2+ -induced MPT ( in vivo supplementation with two distinct antioxidants, CoQ10 and creatine

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These results inform dosing decisions because they show that higher doses generally produce more weight loss, but the incremental benefit between 10 mg and 15 mg is smaller than between 5 mg and 10 mg