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This research was funded by COST Action DIVERSICROP (CA22146), supported by COST (European Cooperation in Science and Technology)

48 GSH synthesis also links the transsulfuration pathway with glutamine metabolism, which upregulated by many oncogenic insults and mutations

Moreover, beyond the pharmacological exigencies, there are other challenges concerning its parasitic nature, such as its great genetic plasticity and adaptability, enabling it to activate a battery of genes to develop resistance quickly