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It is well-know that EDHF (endothelial derived hyperpolarizing factor) besides NO and PGI2 (prostacyclin) plays also important roles for vascular tone [48-50]

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The effect of tripeptide-copper complex on human hair growth in vitro

They dont cite the Shyng paper, but they do refer to the compounds as lysosomotropic agents, and they cite work from the Caughey lab indicating that PrP Sc undergoes beta cleavage in the lysosome [Caughey 1991] (more on this below)