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Kim J, Cha Y-N, Surh Y-J (2010) A protective role of nuclear factor-erythroid 2-related factor-2 (Nrf2) in inflammatory disorders

Subsequently, pharmacologic inhibition of CD38 in LPS and IFN stimulated primary human astrocytes, phenocopied the murine studies and showed that the inhibition of NAD + hydrolysis in these cells, decreased chemokine signaling (72), supporting that astrocytic NAD + biology may play an important role in human neuroinflammation