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A recent study shows that IL-22 expression is significantly increased in the liver of female mice with APAP-induced hepatotoxicity, indicating the necessity to consider gender-dependent effects when using mice to establish a pathophysiological model of IL-22 [205]

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Therefore, PDT not only directly destroys the tumor cells in the irradiated area, but also activates the immune system of the body, recognizes and attacks distant tumor cells that are not directly affected by PDT, and achieves systemic anti-tumor immune effect