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These results demonstrate that chronic and sustained retinal BF dysfunction also induces RGC death, similarly to models of rapid and transient retinal BF reduction

Ethical responsibilities Protection of people and animals The authors declare that no experiments were performed on human beings or animals for this research

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Moreover, considering the critical role of EVs in the antioxidant system, their regulation of the Nrf2 pathway via miRNA cargo may represent an important therapeutic target for intervening in oxidative stress and related diseases