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However, the TNF or P65-mediated activation was significantly reduced when using the EAAT3 promoter-derived luciferase reporter with a single motif mutation, either Mut A or Mut B

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At present, the pathogenesis of DPN has not been clarified, and its insidious onset and lack of obvious symptoms in most patients in the early stages often lead to delayed diagnosis, which is unfavourable for prevention and treatment