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Finally, the early literature mainly features small, single-centre positive trials, suggesting a potential publication bias, as neutral or negative studies are less likely to be published

Common symptoms of autoimmune hepatitis include: Fatigue that feels persistent and unrelieved by sleep Joint pain or aches , especially without visible swelling Upper right abdominal discomfort or tenderness near the liver Jaundice , or yellowing of the skin and eyes Dark-colored urine or light/clay-colored stools Unexplained nausea or loss of appetite Itchy skin (pruritus), even without a rash Spider veins or visible blood vessels on the skin Menstrual irregularities or missed periods (especially in premenopausal women) Brain fog or difficulty concentrating (hepatic encephalopathy in severe cases) Swelling in the legs or abdomen (in advanced liver disease) During menopause , lower levels of estrogen and progesterone may disrupt immune regulation, increasing the risk of autoimmune flare-ups affecting the liver

On the other hand, PLD2 is involved in cell migration and proliferation owing to epidermal growth factor receptor (EGFR) synthesis, as well as in the formation and transport of secretory vesicles and endocytosis, and also in cytoskeleton rearrangement [85, 87, 88]