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As of 2026, neither CJC-1295 nor Ipamorelin is approved by any regulatory authority (FDA, EMA, ANSM)

It also inhibits the production of pro-inflammatory cytokines (TNF-, IL-6, excess TGF-) while stimulating anti-inflammatory cytokines (IL-10)

Species-specific differences in receptor distribution further complicate extrapolation from preclinical models to humans, and the presence of these receptors in peripheral tissues raises concerns regarding off-target uptake (Zhang et al., 2020)