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Studies utilizing genetic knockdowns or pharmacological inhibitors have shown that disruption of one antioxidant system often leads to compensatory upregulation and increased reliance on the other, underscoring their functional interdependence [45]

Autophagy in the eye: implications for ocular cell health

10.1002/ijc.32608 47 De VeraA

Clinically, I have seen that having the MTHFR variation doesnt necessarily mean one is destined for a lot of health challenges and symptoms, and having a greater number of variations doesnt always mean the person will have more symptoms