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105107 Despite the pervasive role of oxidative stress in the pathogenesis of multiorgan failure, the development of antioxidant strategies to counteract oxidative stress has not met with great success in clinical trials

Peroxisomes In peroxisomes [vii] the main source of ROS is the reduction of glycolate [viii] to glyoxylate by glycolate oxidase which uses O 2 to give H 2 O 2