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When glutathione stores are depleted by overproduction of this metabolite, however, the reactive metabolite binds to liver cell proteins and causes hepatic necrosis

de Kloet ER, Jols M, Holsboer F

Moreover, a diet supplemented with EA mitigates oxidative stress during colitis by bolstering Nrf2 signaling pathways in piglets treated with paraquat, protecting against intestinal injury by facilitating the maintenance of tight junction structure and intestinal barrier integrity, while also preserving jejunal and ileal morphology, including villus height, goblet cell number, and the ratio of villus height to crypt depth [349]

Intercellular transfer of mitochondrial DNA carrying metastasis-enhancing pathogenic mutations from high- to low-metastatic tumor cells and stromal cells via extracellular vesicles