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From the size and sequence diversity within the GST superfamily in Arabidopsis , it is clear that there is scope for considerable functional diversification

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Monocle2 pseudotime analysis further confirmed that, relative to natural aging, the additional effect of HHcy caused endothelial cells to diverge in different directions and accelerated their transition from pre-aging to senescence, as evidenced by the bifurcation at Branch Point 1 (Figure 2K)

(ii) In eukaryotes, 3-hydroxy-3-methylglutaryl-CoA synthase 2 (HMG synthase 2) catalyzes the condensation of acetoacetyl-CoA with a third acetyl-CoA to form HMG-CoA (Bahnson, 1960