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NSIT drug discoveries are extremely valuable since therapeutic activity within the GI tract is high whereas the risk for systemic exposure that can potentially lead to whole body toxicities is diminished (21)

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More specifically, all of this is framed - qualitatively - in the systems thinking and diagramming notions behind the above-mentioned scientific literature and - quantitatively - in the systems designs that ecosystems and other self-organising systems develop to reinforce energy use (Odum, 1988), also resorting to the algebra of the eMergy theory (Odum, 1996), to the maxiumum power principle (Lotka, 1922) and to the maximum empower principle (Odum, 1988

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